Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Herrero E
PROVIDER: S-EPMC8410554 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Sánchez-Herrero Estela E Serna-Blasco Roberto R Ivanchuk Vadym V García-Campelo Rosario R Dómine Gómez Manuel M Sánchez José M JM Massutí Bartomeu B Reguart Noemi N Camps Carlos C Sanz-Moreno Sandra S Calabuig-Fariñas Silvia S Jantus-Lewintre Eloísa E Arnal Magdalena M Fernández-Orth Dietmar D Calvo Virginia V González-Rumayor Víctor V Provencio Mariano M Romero Atocha A
Molecular oncology 20210618 9
Despite impressive and durable responses, nonsmall cell lung cancer (NSCLC) patients treated with anaplastic lymphoma kinase (ALK) inhibitors (ALK-Is) ultimately progress due to development of resistance. Here, we have evaluated the clinical utility of circulating tumor DNA (ctDNA) profiling by next-generation sequencing (NGS) upon disease progression. We collected 26 plasma and two cerebrospinal fluid samples from 24 advanced ALK-positive NSCLC patients at disease progression to an ALK-I. These ...[more]