TACI haploinsufficiency protects against BAFF-driven humoral autoimmunity in mice.

ABSTRACT: Polymorphisms in TACI, a BAFF family cytokine receptor, are linked to diverse human immune disorders including common variable immunodeficiency (CVID) and systemic lupus erythematosus (SLE). Functional studies of individual variants show modest impacts on surface TACI expression and/or downstream signal transduction, indicating that relatively subtle variation in TACI activity can impact human B-cell biology. However, significant complexity underlies TACI biology, including both positive and negative regulation of physiologic and pathogenic B-cell responses. To model these contradictory events, we compared the functional impact of TACI deletion on separate models of murine SLE driven by T cell-independent and -dependent breaks in B-cell tolerance. First, we studied whether reduced surface

SUBMITTER: Jacobs HM 

PROVIDER: S-EPMC8410679 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature