Disrupting biological sensors of force promotes tissue regeneration in large organisms.

ABSTRACT: Tissue repair and healing remain among the most complicated processes that occur during postnatal life. Humans and other large organisms heal by forming fibrotic scar tissue with diminished function, while smaller organisms respond with scarless tissue regeneration and functional restoration. Well-established scaling principles reveal that organism size exponentially correlates with peak tissue forces during movement, and evolutionary responses have compensated by strengthening organ-level mechanical properties. How these adaptations may affect tissue injury has not been previously examined in large animals and humans. Here, we show that blocking mechanotransduction signaling through the focal adhesion kinase pathway in large animals significantly accelerates wound healing and enhances reg

SUBMITTER: Chen K 

PROVIDER: S-EPMC8421385 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature