Risk of Non-infectious Uveitis with Metformin Therapy in a Large Healthcare Claims Database.

ABSTRACT:

Purpose

To determine if metformin is associated with noninfectious uveitis (NIU).

Methods

Patients in an insurance claims database who initiated metformin (n = 359,139) or other oral anti-diabetic medications (n = 162,847) were followed for NIU development. Both cohort and case-control analyses were performed to assess differing exposure lengths using Cox and conditional logistic regression, respectively.

Results

The hazard ratio (HR) for incident NIU was not significantly different between the metformin and non-metformin cohorts [HR = 1.19, 95% Confidence Interval (CI): 0.92-1.54, P = .19]. The case control analysis similarly showed no association between any metformin use 2 years before the outcome date and NIU [odds ratio (OR) = 0.64, 95% CI: 0.39-1.04, P

SUBMITTER: Sobrin L 

PROVIDER: S-EPMC8423860 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature