Plasma Proteomics of Renal Function: A Transethnic Meta-Analysis and Mendelian Randomization Study.

ABSTRACT:

Background

Studies on the relationship between renal function and the human plasma proteome have identified several potential biomarkers. However, investigations have been conducted largely in European populations, and causality of the associations between plasma proteins and kidney function has never been addressed.

Methods

A cross-sectional study of 993 plasma proteins among 2882 participants in four studies of European and admixed ancestries (KORA, INTERVAL, HUNT, QMDiab) identified transethnic associations between eGFR/CKD and proteomic biomarkers. For the replicated associations, two-sample bidirectional Mendelian randomization (MR) was used to investigate potential causal relationships. Publicly available datasets and transcriptomic data from independent studies were u

SUBMITTER: Matias-Garcia PR 

PROVIDER: S-EPMC8425654 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature