Chronic Toxoplasma gondii infection enhances susceptibility to colitis.
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ABSTRACT:
SUBMITTER: Saraav I
PROVIDER: S-EPMC8433586 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Chronic <i>Toxoplasma gondii</i> infection enhances susceptibility to colitis.
Saraav Iti I Cervantes-Barragan Luisa L Olias Philipp P Fu Yong Y Wang Qiuling Q Wang Leran L Wang Yi Y Mack Matthias M Baldridge Megan T MT Stappenbeck Thaddeus T Colonna Marco M Sibley L David LD
Proceedings of the National Academy of Sciences of the United States of America 20210901 36
Oral infection with <i>Toxoplasma gondii</i> results in dysbiosis and enteritis, both of which revert to normal during chronic infection. However, whether infection leaves a lasting impact on mucosal responses remains uncertain. Here we examined the effect of the chemical irritant dextran sodium sulfate (DSS) on intestinal damage and wound healing in chronically infected mice. Our findings indicate that prior infection with <i>T. gondii</i> exacerbates damage to the colon caused by DSS and impai ...[more]
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