Ontology highlight
ABSTRACT:
SUBMITTER: Kye YC
PROVIDER: S-EPMC8442933 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Kye Yoon-Chul YC Lee Gil-Woo GW Lee Sung-Woo SW Ju Young-Jun YJ Kim Hee-Ok HO Yun Cheol-Heui CH Cho Jae-Ho JH
Science advances 20210901 36
Naïve CD8<sup>+</sup> T cell quiescence is maintained at a steady state. Although this state of quiescence involves various cell-intrinsic and cell-extrinsic regulators, the mechanisms underlying this regulation remain incompletely understood. Here, we found that signal transducer and activator of transcription 1 (STAT1), a key transcription factor downstream of interferon receptor (IFNR) signaling, plays a cell-intrinsic role in maintaining naïve CD8<sup>+</sup> T cell quiescence. STAT1-deficie ...[more]