Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial.

ABSTRACT:

Aims

Hydroxychloroquine has been suggested as possible treatment for severe acute respiratory syndrome-coronavirus-2. Studies reported an increased risk of QTcF-prolongation after treatment with hydroxychloroquine. The aim of this study was to analyse the concentration-dependent effects of hydroxychloroquine on the ventricular repolarization, including QTcF-duration and T-wave morphology.

Methods

Twenty young (≤30 y) and 20 elderly (65-75 y) healthy male subjects were included. Subjects were randomized to receive either a total dose of 2400 mg hydroxychloroquine over 5 days, or placebo (ratio 1:1). Follow-up duration was 28 days. Electrocardiograms (ECGs) were recorded as triplicate at baseline and 4 postdose single recordings, followed by hydroxychloroquine concentration me

SUBMITTER: Eveleens Maarse BC 

PROVIDER: S-EPMC8444885 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature