Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa.
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ABSTRACT:
SUBMITTER: Ahuno ST
PROVIDER: S-EPMC8448727 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa.
Ahuno Samuel Terkper ST Doebley Anna-Lisa AL Ahearn Thomas U TU Yarney Joel J Titiloye Nicholas N Hamel Nancy N Adjei Ernest E Clegg-Lamptey Joe-Nat JN Edusei Lawrence L Awuah Baffour B Song Xiaoyu X Vanderpuye Verna V Abubakar Mustapha M Duggan Maire M Stover Daniel G DG Nyarko Kofi K Bartlett John M S JMS Aitpillah Francis F Ansong Daniel D Gardner Kevin L KL Boateng Felix Andy FA Bowcock Anne M AM Caldas Carlos C Foulkes William D WD Wiafe Seth S Wiafe-Addai Beatrice B Garcia-Closas Montserrat M Kwarteng Alexander A Ha Gavin G Figueroa Jonine D JD Polak Paz P
NPJ precision oncology 20210917 1
Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients. ...[more]
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