Effect of Early High-Dose Vitamin D3 Repletion on Cognitive Outcomes in Critically Ill Adults.

ABSTRACT:

Background

Long-term cognitive impairment frequently occurs after critical illness; no treatments are known to improve long-term cognition.

Research question

Does a single high-dose (540,000 International Units) enteral treatment of vitamin D3 given shortly after hospital admission in critically ill patients who are vitamin D deficient improve long-term global cognition or executive function?

Study design and methods

This study evaluated long-term cognitive outcomes among patients enrolled in a multicenter, blinded, randomized clinical trial comparing vitamin D3 treatment vs placebo in critically ill adults with vitamin D deficiency. Global cognition was measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Executive function was

SUBMITTER: Han JH 

PROVIDER: S-EPMC8449000 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature