Sex-Specific Catabolic Metabolism Alterations in the Critically Ill following High Dose Vitamin D.

ABSTRACT: Pharmacological interventions are essential for the treatment and management of critical illness. Although women comprise a large proportion of the critically ill, sex-specific pharmacological properties are poorly described in critical care. The sex-specific effects of vitamin D3 treatment in the critically ill are not known. Therefore, we performed a metabolomics cohort study with 1215 plasma samples from 428 patients from the VITdAL-ICU trial to study sex-specific differences in the metabolic response to critical illness following high-dose oral vitamin D3 intervention. In women, despite the dose of vitamin D3 being higher, pharmacokinetics demonstrated a lower extent of vitamin D3 absorption compared to men. Metabolic response to high-dose oral vitamin D3 is sex-specific. Sex-stratifie

SUBMITTER: Chary S 

PROVIDER: S-EPMC8953844 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature