Discrimination of SIRS from Sepsis in Critically Ill Adults

ABSTRACT: Background: Systemic inflammation is a whole body reaction that can have an infection-positive (i.e. sepsis) or infection-negative origin. It is important to distinguish between septic and non-septic presentations early and reliably, because this has significant therapeutic implications for critically ill patients. We hypothesized that a molecular classifier based on a small number of RNAs expressed in peripheral blood could be discovered that would: 1) determine which patients with systemic inflammation had sepsis; 2) be robust across independent patient cohorts; 3) be insensitive to disease severity; and 4) provide diagnostic utility. The overall goal of this study was to identify and validate such a molecular classifier. Methods and Findings: We conducted an observational, non-intervent

ORGANISM(S): Homo sapiens

SUBMITTER: Leo McHugh 

PROVIDER: E-GEOD-74224 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress