The temporal course of T- and B-cell responses to vaccination with BNT162b2 and mRNA-1273.

ABSTRACT:

Objectives

To investigate the response of the immune system (and its influencing factors) to vaccination with BNT162b2 or mRNA-1273.

Methods

531 vaccinees, recruited from healthcare professionals, donated samples before, in between, and after the administration of the two doses of the vaccine. T- and B-cell responses were examined via interferon-γ (IFN-γ) release assay, and antibodies against different epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (S1 and NCP) were detected via ELISA and surrogate neutralization assay. Results were correlated with influencing factors such as age, sex, prior infection, vaccine received (BNT162b2 or mRNA-1273), and immunosuppression. Furthermore, antinuclear antibodies (ANAs) were measured to screen for autoimmune re

SUBMITTER: Markewitz R 

PROVIDER: S-EPMC8450229 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature