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Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici.

ABSTRACT: Inonotus nidus-pici is a sterile conk which produces macrofungus, a neglected Central-Eastern European relative of the prized Inonotus obliquus, also known as chaga. Investigation of the methanol extract of the poroid fungus I. nidus-pici resulted in the isolation of citropremide (1), 3,4-dihydroxybenzalacetone (2) , lanosterol (3), ergost-6,8,22-trien-3β-ol (4), and ergosterol peroxide (5). The structures of fungal compounds were determined on the basis of one- and two-dimensional NMR and MS spectroscopic analysis. Compounds 1-2 and 4-5 were evaluated for their antioxidant and antimicrobial properties against several bacterial and fungal strains. 3,4-dihydroxybenzalacetone (2) and ergost-6,8,22-trien-3β-ol (4) demonstrated moderate antimicrobial activity, while the former possessed notable antioxidant activity in DPPH assay. The antiproliferative examinations performed on three human cancer (MES-SA, MES-SA/Dx5, A431) cell lines demonstrated that compounds 4 and 5 have notable cytotoxic activity with IC values in micromolar range. The current study represents the first report on the chemical profile of I. nidus-pici, providing a comprehensive study on the isolation and structure determination of bioactive secondary metabolites of this macrofungus.

SUBMITTER: Garadi Z

PROVIDER: S-EPMC8468361 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici.

Garádi Zsófia Z Dékány Miklós M Móricz Ágnes M ÁM Gaál Anikó A Papp Viktor V Béni Szabolcs S Ványolós Attila A

Molecules (Basel, Switzerland) 20210907 18

Inonotus nidus-pici is a sterile conk which produces macrofungus, a neglected Central-Eastern European relative of the prized Inonotus obliquus, also known as chaga. Investigation of the methanol extract of the poroid fungus I. nidus-pici resulted in the isolation of citropremide (1), 3,4-dihydroxybenzalacetone (2) , lanosterol (3), ergost-6,8,22-trien-3β-ol (4), and ergosterol peroxide (5). The structures of fungal compounds were determine ...[more]

PMID: 34576923

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Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from Inonotus nidus-pici.

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Antimicrobial, Antioxidant and Antiproliferative Secondary Metabolites from <i>Inonotus nidus-pici</i>.

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