Leptin Decreases Energy Expenditure Despite Increased Thyroid Hormone in Patients With Lipodystrophy.

ABSTRACT:

Context

Leptin is an adipokine that signals energy sufficiency. In rodents, leptin deficiency decreases energy expenditure (EE), which is corrected following leptin replacement. In humans, data are mixed regarding leptin-mediated effects on EE.

Objective

To determine the effects of metreleptin on EE in patients with lipodystrophy.

Design, setting, and patients

Nonrandomized crossover study of 25 patients with lipodystrophy (National Institutes of Health, 2013-2018).

Intervention

The initiation cohort consisted of 17 patients without prior exposure to metreleptin, studied before and after 14 days of metreleptin. The withdrawal cohort consisted of 8 previously metreleptin-treated patients, studied before and after 14 days of metreleptin withdrawal.

Main outcom

SUBMITTER: Grover A 

PROVIDER: S-EPMC8475236 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature