Ontology highlight
ABSTRACT:
SUBMITTER: Han YH
PROVIDER: S-EPMC8478306 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Han Yong-Hyun YH Onufer Emily J EJ Huang Li-Hao LH Sprung Robert W RW Davidson W Sean WS Czepielewski Rafael S RS Wohltmann Mary M Sorci-Thomas Mary G MG Warner Brad W BW Randolph Gwendalyn J GJ
Science (New York, N.Y.) 20210701 6553
The biogenesis of high-density lipoprotein (HDL) requires apoA1 and the cholesterol transporter ABCA1. Although the liver generates most of the HDL in the blood, HDL synthesis also occurs in the small intestine. Here, we show that intestine-derived HDL traverses the portal vein in the HDL<sub>3</sub> subspecies form, in complex with lipopolysaccharide (LPS)-binding protein (LBP). HDL<sub>3</sub>, but not HDL<sub>2</sub> or low-density lipoprotein, prevented LPS binding to and inflammatory activa ...[more]