Impact of Structural Changes on Multifocal Electroretinography in Patients With Use of Hydroxychloroquine.

ABSTRACT:

Purpose

To investigate the relationship between retinal structure and macular function in eyes screened for hydroxychloroquine (HCQ) toxicity.

Methods

Participants referred for hydroxychloroquine retinopathy screening with spectral domain optical coherence tomography (SD-OCT) and multifocal electroretinogram (mfERG) testing were included in the analysis. Amplitude and implicit time of mfERG N1 and P1 responses were included in the analysis. Ring ratios were computed for amplitude values as the ratio of rings 1-3:5 (R1-3:R5). A control group of healthy participants was included for comparison of SD-OCT metrics.

Results

Sixty-three eyes screened for HCQ retinopathy and 30 control eyes were analyzed. The outer nuclear layer (ONL) was significantly thinner in HCQ patients

SUBMITTER: Borrelli E 

PROVIDER: S-EPMC8479571 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature