Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn's Disease.

ABSTRACT:

Background and aims

Crohn's disease and ulcerative colitis are characterized by dysregulated adaptive immune responses to the microbiota in genetically susceptible individuals, but the specificity of these responses remains largely undefined. Therefore, we developed a microbiota antigen microarray to characterize microbial antibody reactivity, particularly to human-derived microbiota flagellins, in inflammatory bowel disease.

Methods

Sera from healthy volunteers (n = 87) at the University of Alabama at Birmingham and from patients recruited from the Kirklin Clinic of University of Alabama at Birmingham Hospital, including patients with Crohn's disease (n = 152) and ulcerative colitis (n = 170), were individually probed against microbiota bacterial flagellins of both mouse an

SUBMITTER: Alexander KL 

PROVIDER: S-EPMC8489510 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature