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Copper-catalyzed monoselective C-H amination of ferrocenes with alkylamines.

ABSTRACT: A copper-catalyzed mono-selective C-H amination of ferrocenes assisted by 8-aminoquinoline is presented here. A range of amines, including bioactive molecules, were successfully installed to the ortho-position of ferrocene amides with high efficiency under mild conditions. A range of functionalized ferrocenes were compatible to give the aminated products in moderate to good yields. The gram-scale reaction was smoothly conducted and the directing group could be removed easily under basic conditions.

SUBMITTER: Jia ZS

PROVIDER: S-EPMC8491713 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Copper-catalyzed monoselective C-H amination of ferrocenes with alkylamines.

Jia Zhen-Sheng ZS Yue Qiang Q Li Ya Y Xu Xue-Tao XT Zhang Kun K Shi Bing-Feng BF

Beilstein journal of organic chemistry 20210928

A copper-catalyzed mono-selective C-H amination of ferrocenes assisted by 8-aminoquinoline is presented here. A range of amines, including bioactive molecules, were successfully installed to the <i>ortho</i>-position of ferrocene amides with high efficiency under mild conditions. A range of functionalized ferrocenes were compatible to give the aminated products in moderate to good yields. The gram-scale reaction was smoothly conducted and the directing group could be removed easily under basic c ...[more]

PMID: 34646397

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