SARS-CoV-2 in children with cancer or after haematopoietic stem cell transplant: An analysis of 131 patients.

ABSTRACT:

Purpose

There are limited data on SARS-CoV-2 (COVID-19) infection in children with cancer or after haematopoietic stem cell transplant (HSCT). We describe the severity and outcomes of SARS-COV-2 in these patients and identify factors associated with severe disease.

Methods

This was a multinational, observational study of children (aged <19 years) with cancer or HSCT and SARS-CoV-2 confirmed by polymerase chain reaction. COVID-19 was classified as asymptomatic, mild, moderate, severe or critical (≥1 organ support). Exact polytomous regression was used to determine the relationship between clinical variables and disease severity.

Results

One hundred and thirty-one patients with COVID-19 across 10 countries were identified (median age 8 years). Seventy-eight (60%) had le

SUBMITTER: Haeusler GM 

PROVIDER: S-EPMC8501219 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature