Correlation between BAL CXCR3 chemokines and lung allograft histopathologies: A multicenter study.

ABSTRACT: The histopathologic diagnosis of acute allograft injury is prognostically important in lung transplantation with evidence demonstrating a strong and consistent association between acute rejection (AR), acute lung injury (ALI), and the subsequent development of chronic lung allograft dysfunction (CLAD). The pathogenesis of these allograft injuries, however, remains poorly understood. CXCL9 and CXCL10 are CXC chemokines induced by interferon-γ and act as potent chemoattractants of mononuclear cells. We hypothesized that these chemokines are involved in the mononuclear cell recruitment associated with AR and ALI. We further hypothesized that the increased activity of these chemokines could be quantified as increased levels in the bronchoalveolar lavage fluid. In this prospective multicenter s

SUBMITTER: Shino MY 

PROVIDER: S-EPMC8502500 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature