Oestrogen-regulated protein SLC39A6: a biomarker of good prognosis in luminal breast cancer.

ABSTRACT:

Purpose

The outcome of the luminal oestrogen receptor-positive (ER +) subtype of breast cancer (BC) is highly variable and patient stratification needs to be refined. We assessed the prognostic significance of oestrogen-regulated solute carrier family 39 member 6 (SLC39A6) in BC, with emphasis on ER + tumours.

Materials and methods

SLC39A6 mRNA expression and copy number alterations were assessed using the METABRIC cohort (n = 1980). SLC39A6 protein expression was evaluated in a large (n = 670) and annotated series of early-stage (I-III) operable BC using tissue microarrays and immunohistochemistry. The associations between SLC39A6 expression and clinicopathological parameters, patient outcomes and other ER-related markers were evaluated using Chi-square tests and Kaplan-Mei

SUBMITTER: Althobiti M 

PROVIDER: S-EPMC8505289 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature