The proliferation role of LH on porcine primordial germ cell-like cells (pPGCLCs) through ceRNA network construction.

ABSTRACT:

Background

The transdifferentiation of skin-derived stem cells (SDSCs) into primordial germ cell-like cells (PGCLCs) is one of the major breakthroughs in the field of stem cells research in recent years. This technology provides a new theoretical basis for the treatment of human infertility. However, the transdifferentiation efficiency of SDSCs to PGCLCs is very low, and scientists are still exploring ways to improve this efficiency or promote the proliferation of PGCLCs. This study aims to investigate the molecular mechanism of luteinising hormone (LH) to enhance porcine PGCLCs (pPGCLCs) proliferation.

Results

In this study, we dissected the proliferation regulatory network of pPGCLCs by whole transcriptome sequencing, and the results showed that the pituitary-secreted repr

SUBMITTER: Zhang MY 

PROVIDER: S-EPMC8516341 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature