Dataset Information

Neuroanatomical correlates of reality monitoring in patients with schizophrenia and auditory hallucinations.

ABSTRACT:

Background

Reality-monitoring process enables to discriminate memories of internally generated information from memories of externally derived information. Studies have reported impaired reality-monitoring abilities in schizophrenia patients with auditory hallucinations (AHs), specifically with an exacerbated externalization bias, as well as alterations in neural activity within frontotemporoparietal areas. In healthy subjects, impaired reality-monitoring abilities have been associated with reduction of the paracingulate sulcus (PCS). The current study aimed to identify neuroanatomical correlates of reality monitoring in patients with schizophrenia.

Methods

Thirty-five patients with schizophrenia and AHs underwent a reality-monitoring task and a 3D anatomical MRI scan at 1.5 T. PCS lengths were measured separately for each hemisphere, and whole-brain voxel-based morphometry analyses were performed using the Computational Anatomy Toolbox (version 12.6) to evaluate the gray-matter volume (GMV). Partial correlation analyses were used to investigate the relationship between reality-monitoring and neuroanatomical outcomes (PCS length and GMV), with age and intracranial volume as covariates.

Results

The right PCS length was positively correlated with reality-monitoring accuracy (Spearman's ρ = 0.431, p = 0.012) and negatively with the externalization bias (Spearman's ρ = -0.379, p = 0.029). Reality-monitoring accuracy was positively correlated with GMV in the right angular gyrus, whereas externalization bias was negatively correlated with GMV in the left supramarginal gyrus/superior temporal gyrus, in the right lingual gyrus and in the bilateral inferior temporal/fusiform gyri (voxel-level p < 0.001 and cluster-level p < 0.05, FDR-corrected).

Conclusions

Reduced reality-monitoring abilities were significantly associated with shorter right PCS and reduced GMV in temporal and parietal regions of the reality-monitoring network in schizophrenia patients with AHs.

SUBMITTER: Perret M

PROVIDER: S-EPMC8516745 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Publications

Neuroanatomical correlates of reality monitoring in patients with schizophrenia and auditory hallucinations.

Perret Mélanie M Lavallé Layla L Haesebaert Frédéric F Suaud-Chagny Marie-Françoise MF Brunelin Jérôme J Mondino Marine M

European psychiatry : the journal of the Association of European Psychiatrists 20210922 1

<h4>Background</h4>Reality-monitoring process enables to discriminate memories of internally generated information from memories of externally derived information. Studies have reported impaired reality-monitoring abilities in schizophrenia patients with auditory hallucinations (AHs), specifically with an exacerbated externalization bias, as well as alterations in neural activity within frontotemporoparietal areas. In healthy subjects, impaired reality-monitoring abilities have been associated w ...[more]

PMID: 34548121

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Project description:Neuroimaging studies have revealed that the mechanisms of auditory hallucinations are related to morphological changes in multiple cortical regions, but studies on brain network properties are lacking. This study aims to construct intra-individual structural covariance networks and reveal network changes related to auditory hallucinations. T1-weighted MRI images were acquired from 90 schizophrenia patients with persistent auditory hallucinations (pAH group), 55 schizophrenia patients without auditory hallucinations (non-pAH group), and 83 healthy controls (HC group). Networks were constructed using the voxel-based gray matter volume and the intra-individual structural covariance was based on the similarity between the morphological variations of any two regions. One-way ANCOVA was employed to compare global and local network metrics among the three groups, and edge analysis was conducted via network-based statistics. In the pAH group, Pearson correlation analysis between network metrics and clinical symptoms was conducted. Compared with the HC group, both the pAH group (p = 0.01) and the non-pAH group (p = 3.56 × 10-4) had lower nodal efficiency of the left medial superior frontal gyrus. Compared to the non-pAH group and HC group, the pAH group presented lower nodal efficiency of the temporal pole of the left superior temporal gyrus (p = 1.09 × 10-3; p = 7.67 × 10-4) and right insula (p = 0.02; p = 8.99 × 10-6), and lower degree centrality of the right insula (p = 0.04; p = 1.65 × 10-5). The pAH group had a subnetwork with reduced structural covariance centered by the left temporal pole of the superior temporal gyrus. In the pAH group, the normalized clustering coefficient (r = -0.36, p = 8.45 × 10-3) and small-worldness (r = -0.35, p = 9.89 × 10-3) were negatively correlated with the PANSS positive scale score. This study revealed network changes in schizophrenia patients with persistent auditory hallucinations, and provided new insights into the structural architecture related to auditory hallucinations at the network level.

Dataset Information

Neuroanatomical correlates of reality monitoring in patients with schizophrenia and auditory hallucinations.

Background

Methods

Results

Conclusions

Publications

Neuroanatomical correlates of reality monitoring in patients with schizophrenia and auditory hallucinations.

Similar Datasets

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