Hybrid Self-Assembled Gel Beads for Tuneable pH-Controlled Rosuvastatin Delivery.

ABSTRACT: This article describes the fabrication of new pH-responsive hybrid gel beads combining the polymer gelator calcium alginate with two different low-molecular-weight gelators (LMWGs) based on 1,3 : 2,4-dibenzylidene-d-sorbitol: pH-responsive DBS-COOH and thermally responsive DBS-CONHNH₂ , thus clearly demonstrating that different classes of LMWG can be fabricated into gel beads by using this approach. We also demonstrate that self-assembled multicomponent gel beads can be formed by using different combinations of these gelators. The different gel bead formulations exhibit different responsiveness - the DBS-COOH network can disassemble within those beads in which it is present upon raising the pH. To exemplify preliminary data for a potential application for these hybrid gel beads,

SUBMITTER: Piras CC 

PROVIDER: S-EPMC8519141 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature