Ontology highlight
ABSTRACT:
SUBMITTER: Kondo M
PROVIDER: S-EPMC8520001 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Kondo Makoto M Kameishi Sumako S Kim Kyungsook K Metzler Nicolas F NF Maak Travis G TG Hutchinson Douglas T DT Wang Angela A AA Maehara Miki M Sato Masato M Grainger David W DW Okano Teruo T
NPJ Regenerative medicine 20211015 1
Knee cartilage does not regenerate spontaneously after injury, and a gold standard regenerative treatment algorithm has not been established. This study demonstrates preclinical safety and efficacy of scaffold-free, human juvenile cartilage-derived-chondrocyte (JCC) sheets produced from routine surgical discards using thermo-responsive cultureware. JCCs exhibit stable and high growth potential in vitro over passage 10, supporting possibilities for scale-up to mass production for commercializatio ...[more]