Identifying hub genes and immune infiltration of osteoarthritis using comprehensive bioinformatics analysis.

ABSTRACT:

Background

Osteoarthritis (OA) is the most common chronic degenerative joint disorder globally that is characterized by synovitis, cartilage degeneration, joint space stenosis, and sub-cartilage bone hyperplasia. However, the pathophysiologic mechanisms of OA have not been thoroughly investigated.

Methods

In this study, we conducted various bioinformatics analyses to identify hub biomarkers and immune infiltration in OA. The gene expression profiles of synovial tissues from 29 healthy controls and 36 OA samples were obtained from the gene expression omnibus database to identify differentially expressed genes (DEGs). The CIBERSORT algorithm was used to explore the association between immune infiltration and arthritis.

Results

Eighteen hub DEGs were identified as critic

SUBMITTER: Wu ZY 

PROVIDER: S-EPMC8527722 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature