T-cell receptor repertoires as potential diagnostic markers for patients with COVID-19.

ABSTRACT:

Objective

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global health emergency. T-cell receptors (TCRs) are crucial mediators of antiviral adaptive immunity. This study sought to comprehensively characterize the TCR repertoire changes in patients with COVID-19.

Methods

A large sample size multi-center randomized controlled trial was implemented to study the features of the TCR repertoire and identify COVID-19 disease-related TCR sequences.

Results

It was found that some T-cell receptor beta chain (TCRβ) features differed markedly between COVID-19 patients and healthy controls, including decreased repertoire diversity, longer complementarity-determining region 3 (CDR3) length, skewed utilizat

SUBMITTER: Hou X 

PROVIDER: S-EPMC8530772 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature