Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review.

ABSTRACT:

Background

Suicide behavior (SB) has been highly associated with the response to stress and the hypothalamic-pituitary-adrenal (HPA) axis. The aim of this study was to summarize the results obtained in genetic studies that analyzed the HPA axis-stress pathway and SB through a systematic review.

Methods

We performed an online search in PubMed, EBSCO, Web of Science, Scopus, and PsycoInfo databases up to May 2021. We followed the PRISMA guidelines for systematic reviews. We included case-control and expression studies that provided data on mRNA expression and single-nucleotide polymorphisms of genes associated with SB.

Results

A total of 21,926 individuals participated across 41 studies (not repeats); 34 studies provided data on single-nucleotide polymorphisms in 21,284

SUBMITTER: Hernandez-Diaz Y 

PROVIDER: S-EPMC8536196 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature