Enrofloxacin Alters Fecal Microbiota and Resistome Irrespective of Its Dose in Calves.
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ABSTRACT:
SUBMITTER: Beyi AF
PROVIDER: S-EPMC8537546 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
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Enrofloxacin Alters Fecal Microbiota and Resistome Irrespective of Its Dose in Calves.
Beyi Ashenafi Feyisa AF Brito-Goulart Debora D Hawbecker Tyler T Ruddell Brandon B Hassall Alan A Dewell Renee R Dewell Grant G Sahin Orhan O Zhang Qijing Q Plummer Paul J PJ
Microorganisms 20211017 10
Enrofloxacin is a fluoroquinolone drug used to prevent and control bovine respiratory disease (BRD) complex in multiple or single doses, ranging from 7.5 to 12.5 mg/kg body weight. Here, we examined the effects of high and low doses of a single subcutaneously injected enrofloxacin on gut microbiota and resistome in calves. Thirty-five calves sourced for this study were divided into five groups: control (<i>n</i> = 7), two low dose groups (<i>n</i> = 14, 7.5 mg/kg), and two high dose groups (<i>n ...[more]
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