Expression and prognostic potential of ribosome 18S RNA m⁶A methyltransferase METTL5 in gastric cancer.

ABSTRACT:

Background

Ribosomal RNA N6-methyltransferase METTL5 was reported to catalyze m⁶A in 18S rRNA. We aimed to investigate the expression and prognostic features of METTL5 in gastric cancer (GC).

Methods

In this study, 168 GC patients and their corresponding adjacent tissues were collected. Immunohistochemical staining was used to detect the expression of METTL5 protein. Univariate and multivariate Cox analysis were used to dertermine the prognostic role of METTL5 protein in GC, and a nomogram was constructed to evaluate GC patients' prognosis based on METTL5 expression. Data from TCGA and GEO database were also used to validate the prognostic value of METTL5 in GC patients on mRNA level. We further performed GSEA enrichment analysis to explore the possible function a

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8549223 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature