Hippocampal Lnx1-NMDAR multiprotein complex mediates initial social memory.

ABSTRACT: Social interaction and communication are evolutionary conserved behaviours that are developed in mammals to establish partner cognition. Deficit in sociability has been represented in human patients and animal models of neurodevelopmental disorders, which are connected with genetic variants of synaptic glutamate receptors and associated PDZ-binding proteins. However, it remains elusive how these key proteins are specialized in the cellular level for the initial social behaviour during postnatal developmental stage. Here we identify a hippocampal CA3 specifically expressed PDZ scaffold protein Lnx1 required for initial social behaviour. Through gene targeting we find that Lnx1 deficiency led to a hippocampal subregional disorder in neuronal activity and social memory impairments for partner

SUBMITTER: Liu XD 

PROVIDER: S-EPMC8550978 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature