Immune microenvironment composition in high-grade serous ovarian cancers based on BRCA mutational status.

ABSTRACT:

Purpose

An in-depth analysis of the tumor microenvironment of ovarian cancer is needed. The purpose of this study was to elucidate the architecture of the immune microenvironment of high-grade serous ovarian cancers (HGSCs) with or without BRCA1 and BRCA2 mutations.

Methods

A cohort of highly annotated HGSC patients with known germline BRCA1 and BRCA2 status was selected, and pretreatment tumor tissue specimens were analyzed with a multiplexed staining technique aimed at detecting lymphocytes, macrophages, and fibroblasts in the whole tumor area and in specific regions including epithelium, stroma, and perivascular areas.

Results

BRCA1- or BRCA2-mutated tumors showed a more immunogenic microenvironment, characterized by a higher abundance of CD8⁺ and PD-L1<

SUBMITTER: Corvigno S 

PROVIDER: S-EPMC8557133 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature