Inhibition of transient receptor potential vanilloid type 1 through α₂ adrenergic receptors at peripheral nerve terminals relieves pain.

ABSTRACT: The activation of α₂ adrenergic receptors contributes to analgesia not only in the central nervous system but also in the peripheral nervous system. We reported that noradrenaline inhibits the activity of transient receptor potential vanilloid 1 (TRPV1) evoked by capsaicin through α₂ receptors in cultured rat dorsal root ganglion (DRG) neurons. However, it is unclear whether activation of TRPV1 expressed in peripheral nerve terminals is inhibited by α₂ receptors and whether this phenomenon contributes to analgesia. Therefore, we examined effects of clonidine, an α₂ receptor agonist, on several types of nociceptive behaviors, which may be caused by TRPV1 activity, and subtypes of α₂ receptors expressed with TRPV1 in primary sensory neur

SUBMITTER: Matsushita Y 

PROVIDER: S-EPMC8569874 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature