ID2 Inhibits Bladder Cancer Progression and Metastasis via PI3K/AKT Signaling Pathway.

ABSTRACT: Background: Inhibitors of DNA-binding (ID) proteins are important regulators of cell proliferation and differentiation. The aim of this study was to evaluated the role of ID proteins in bladder cancer (BCa) and related molecular mechanisms. Methods: The TCGA database was analyzed for the expression and clinical significance of ID proteins. The expression of ID2 was determined by qRT-PCR, immunohistochemical staining and western blot. The role of ID2 was determined by CCK-8, colony formation, wound healing, transwell and xenograft tumor assays, and the potential mechanism of ID2 in BCa was investigated by RNA sequencing. Results: ID2 expression was significantly downregulated in TCGA database and clinical samples, and high ID2 expression was associated with low-grade tu

SUBMITTER: Mao W 

PROVIDER: S-EPMC8570141 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature