M6A regulator-mediated RNA methylation modification patterns and immune microenvironment infiltration characterization in severe asthma.

ABSTRACT: N6-methyladenosine (m6A) modification is one of the most prevalent RNA modification forms of eukaryotic mRNA and is an important post-transcriptional mechanism for regulating genes. However, the role of m6A modification in the regulation of severe asthma has never been reported. Thus, we aimed to investigate the m6A regulator-mediated RNA methylation modification patterns and immune microenvironment infiltration characterization in severe asthma. In this study, 87 healthy controls and 344 severe asthma cases from the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes) programme were used to systematically evaluate the m6A modification patterns mediated by 27 m6A regulators and to investigate the effects of m6A modification on immune microenvironment character

SUBMITTER: Sun D 

PROVIDER: S-EPMC8572790 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature