The Role of Long Non-coding RNAs in Human Imprinting Disorders: Prospective Therapeutic Targets.

ABSTRACT: Genomic imprinting is a term used for an intergenerational epigenetic inheritance and involves a subset of genes expressed in a parent-of-origin-dependent way. Imprinted genes are expressed preferentially from either the paternally or maternally inherited allele. Long non-coding RNAs play essential roles in regulating this allele-specific expression. In several well-studied imprinting clusters, long non-coding RNAs have been found to be essential in regulating temporal- and spatial-specific establishment and maintenance of imprinting patterns. Furthermore, recent insights into the epigenetic pathological mechanisms underlying human genomic imprinting disorders suggest that allele-specific expressed imprinted long non-coding RNAs serve as an upstream regulator of the expression of other pro

SUBMITTER: Wang T 

PROVIDER: S-EPMC8573313 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature