The expression of STEAP4 in peripheral blood predicts the outcome of septic patients.

ABSTRACT:

Background

Sepsis is a systemic disease characterized by extensive inflammatory responses and impaired organ function, which are characteristics that make it easily missed and complex to treat. A large number of laboratory and clinical studies on the diagnosis and treatment of sepsis have been continuously carried out, confirming the importance of mitochondrial function during the development of sepsis. STEAP4 is an important metalloreductase in mitochondria, which is involved in the biogenesis and respiratory chain of mitochondria. The role of STEAP4 in inflammation remains controversial. Research in this field may contribute to the development of new diagnostic and treatment options for sepsis.

Methods

The expression of STEAP4 was measured in the peripheral blood of patien

SUBMITTER: Jiang H 

PROVIDER: S-EPMC8576732 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature