Multifunctional, TNF-α and IFN-γ-Secreting CD4 and CD8 T Cells and CD8^High T Cells Are Associated With the Cure of Human Visceral Leishmaniasis.

ABSTRACT: Visceral leishmaniasis (VL) is a chronic and often fatal disease caused by protozoans of the genus Leishmania that affects millions of people worldwide. Patients with symptomatic VL have an impaired anti-Leishmania-specific CD4⁺ T-cell response, which is reversed after clinical cure. In contrast, the quality of the CD4⁺ and CD8⁺ T-cell responses involved in resistance and/or cure of VL relies on the capability of these cells to activate polyfunctional and memory responses, which are associated with the simultaneous production of three cytokines: IFN-γ, IL-2, and TNF-α. Models for the development of CD4 and CD8 T-cell quality in memory and protection to leishmaniasis have been described previously. We aimed to assess the functionality of the T

SUBMITTER: Rodrigues LS 

PROVIDER: S-EPMC8581227 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature