Phosphorus bioaccessibility measured in four amino acid-based  formulas using in-vitro batch digestion translates well into phosphorus bioavailability in mice.

ABSTRACT:

Objective

The aim of this study was to quantify the bioaccessibility of phosphorus from amino acid-based formulas (AAFs) under different digestive conditions.

Methods

We developed in-vitro batch digestion models with stomach digestion at different pH mimicking the normal digestive condition and conditions representing use of acid-suppressive medication. To validate bioaccessibility findings, we devised a low phosphorus murine model to test phosphorus bioavailability under compromised digestive conditions using proton pump inhibitors (PPIs) to neutralize stomach pH.

Results

In vitro phosphorus bioaccessibility of AAFs Neocate® Infant and Neocate Junior ranged between 57% and 65% under normal digestive conditions for infants (stomach pH 3.5) and between 38% and 46% unde

SUBMITTER: Chande S 

PROVIDER: S-EPMC8588148 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature