Alcohol consumption induces murine osteoporosis by downregulation of natural killer T-like cell activity.

ABSTRACT:

Introduction

Chronic alcohol consumption (CAC) can induce several deleterious effects on the body, including the promotion of osteoporosis; however, the immunological mechanism underlying alcohol-induced osteoporosis is still unclear.

Methods

We administered alcohol to mice for 4 weeks as the experimental CAC model and analyzed the bone and immune cells that are located in the vicinity of a bone.

Results

IL-4 is known to be a suppressive factor for osteoclastogenesis, and we found that natural killer T (NKT)-like cells, which showed NK1.1-positive, CD3-positive, and α-galactosylceramide-loaded CD1d tetramer-negative, produced IL-4 more effectively than CD4⁺ T and natural killer (NK) cells. The alcohol consumption facilitated a significant decrease of bone m

SUBMITTER: Naruo M 

PROVIDER: S-EPMC8589379 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature