Effects of anticholinergic and sedative medication use on fractures: A self-controlled design study.

ABSTRACT:

Background/objectives

Unintentional falls are a leading cause of injury for older adults, and evidence is needed to understand modifiable risk factors. We evaluated 1-year fall-related fracture risk and whether dispensing of medications with anticholinergic/sedating properties is temporally associated with an increased odds of these fractures.

Design

A retrospective cohort study with nested self-controlled analyses conducted between January 1, 2014, and December 31, 2016.

Setting

Twenty percent nationwide, random sample of US Medicare beneficiaries.

Participants

New users of medications with anticholinergic/sedating properties who were 66+ years old and had Medicare Parts A, B, and D coverage but no claims for medications with anticholinergic/sedating propertie

SUBMITTER: Shmuel S 

PROVIDER: S-EPMC8595585 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature