Association of Retinal Nerve Fiber Layer Thickness, an Index of Neurodegeneration, With Depressive Symptoms Over Time.

ABSTRACT:

Importance

Whether neurodegeneration contributes to the early pathobiology of late-life depression remains incompletely understood.

Objective

To investigate whether lower retinal nerve fiber layer (RNFL) thickness, a marker of neurodegeneration, is associated with the incidence of clinically relevant depressive symptoms and depressive symptoms over time.

Design, setting, and participants

This is a population-based cohort study from the Netherlands (The Maastricht Study) with baseline examination between 2010 and 2020 and median (IQR) follow-up of 5.0 (3.0-6.0) years. Participants were recruited from the general population. Individuals with type 2 diabetes were oversampled by design. Data analysis was performed from September 2020 to January 2021.

Exposures

RNFL

SUBMITTER: van der Heide FCT 

PROVIDER: S-EPMC8596200 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature