Identification of Disease-Related Genes That Are Common between Alzheimer's and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis.

ABSTRACT: Accumulating evidence has suggested a shared pathophysiology between Alzheimer's disease (AD) and cardiovascular disease (CVD). Based on genome-wide transcriptomes, specifically those of blood samples, we identify the shared disease-related signatures between AD and CVD. In addition to gene expressions in blood, the following prior knowledge were utilized to identify several candidate disease-related gene (DRG) sets: protein-protein interactions, transcription factors, disease-gene relationship databases, and single nucleotide polymorphisms. We selected the respective DRG sets for AD and CVD that show a high accuracy for disease prediction in bulk and single-cell gene expression datasets. Then, gene regulatory networks (GRNs) were constructed from each of the AD and CVD DRG sets to identif

SUBMITTER: Lee T 

PROVIDER: S-EPMC8614900 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature