Hugin ⁺ neurons provide a link between sleep homeostat and circadian clock neurons.

ABSTRACT: Sleep is controlled by homeostatic mechanisms, which drive sleep after wakefulness, and a circadian clock, which confers the 24-h rhythm of sleep. These processes interact with each other to control the timing of sleep in a daily cycle as well as following sleep deprivation. However, the mechanisms by which they interact are poorly understood. We show here that hugin ⁺ neurons, previously identified as neurons that function downstream of the clock to regulate rhythms of locomotor activity, are also targets of the sleep homeostat. Sleep deprivation decreases activity of hugin ⁺ neurons, likely to suppress circadian-driven activity during recovery sleep, and ablation of hugin ⁺ neurons promotes sleep increases generated by activation of t

SUBMITTER: Schwarz JE 

PROVIDER: S-EPMC8617458 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature