Time-Updated Changes in Estimated GFR and Proteinuria and Major Adverse Cardiac Events: Findings from the Chronic Renal Insufficiency Cohort (CRIC) Study.

ABSTRACT:

Rationale & objective

Evaluating repeated measures of estimated glomerular filtration rate (eGFR) and urinary protein-creatinine ratio (UPCR) over time may enhance our ability to understand the association between changes in kidney parameters and cardiovascular disease risk.

Study design

Prospective cohort study.

Setting & participants

Annual visit data from 2,438 participants in the Chronic Renal Insufficiency Cohort (CRIC).

Exposures

Average and slope of eGFR and UPCR in time-updated, 1-year exposure windows.

Outcomes

Incident heart failure, atherosclerotic cardiovascular disease events, death, and a composite of incident heart failure, atherosclerotic cardiovascular disease events, and death.

Analytical approach

A landmark analysis, a dynamic a

SUBMITTER: Cohen JB 

PROVIDER: S-EPMC8627522 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature