Global geographic differences in healthcare utilization for sickle cell disease pain crises in the CASiRe cohort.

ABSTRACT:

Background

Sickle cell disease (SCD) is characterized by frequent, unpredictable pain episodes and other vaso-occlusive crises (VOCs) leading to significant healthcare utilization. VOC frequency is often an endpoint in clinical trials investigating novel therapies for this devastating disease.

Procedure

The Consortium for the Advancement of Sickle Cell Research (CASiRe) is an international collaboration investigating clinical severity in SCD using a validated questionnaire and medical chart review standardized across four countries (United States, United Kingdom, Italy and Ghana).

Results

This study, focused on pain crisis incidence and healthcare utilization, included 868 patients, equally represented according to age and gender. HgbSS was the most common genotype. P

SUBMITTER: Strunk C 

PROVIDER: S-EPMC8643307 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature