Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson's disease.

ABSTRACT:

Background

Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson's disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials.

Methods

Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study.

Results

Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients

SUBMITTER: Martinez-Horta S 

PROVIDER: S-EPMC8653592 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature