Ontology highlight
ABSTRACT:
SUBMITTER: Herbst DA
PROVIDER: S-EPMC8660637 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Herbst Dominik A DA Esbin Meagan N MN Louder Robert K RK Dugast-Darzacq Claire C Dailey Gina M GM Fang Qianglin Q Darzacq Xavier X Tjian Robert R Nogales Eva E
Nature structural & molecular biology 20211122 12
The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification, DNA damage repair and signaling. While structures of yeast SAGA (ySAGA) have been reported, there are noteworthy functional and compositional differences for this complex in metazoans. Here we present the cryogenic-electron microscopy (cryo-EM) structure of human SAGA (hSAGA) and show how the arrangement of distinct structural elements results in a globally divergent organization from that of yeast, with a ...[more]