Transcriptome sequencing reveals a lncRNA-mRNA interaction network in extramammary Paget's disease.

ABSTRACT:

Background

Extramammary Paget's disease (EMPD) is a rare malignant intraepidermal adenocarcinoma that is poorly understood. Regulatory long noncoding RNAs (lncRNAs) are characterized in many species and shown to be involved in processes such as development and pathologies, revealing a new layer of regulation in different diseases, especially in cancer studies. In the present study, we used high-throughput sequencing to reveal the lncRNA-mRNA interaction network in extramammary Paget's disease.

Methods

High-throughput sequencing was used to identify differentially expressed lncRNA and mRNA profiles between EMPD patients and healthy controls. Then, a series of bioinformatics analyses were conducted to construct the lncRNA-mRNA interaction network, which was finally confirmed i

SUBMITTER: Zheng DC 

PROVIDER: S-EPMC8665522 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature